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Home - Products - Cytoskeleton/Cell Adhesion Molecules - HSP - Col 003

Col 003

CAS No. 328565-16-8

Col 003( Col003 )

Catalog No. M14076 CAS No. 328565-16-8

Col 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 98 Get Quote
25MG 205 Get Quote
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Biological Information

  • Product Name
    Col 003
  • Note
    Research use only, not for human use.
  • Brief Description
    Col 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM.
  • Description
    Col 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM, binds to the collagen-binding site on Hsp47; competitively inhibits the interaction and causes the inhibition of collagen secretion by destabilizing the collagen triple helix.
  • In Vitro
    Western Blot Analysis Cell Line:Wild-type MEFs Concentration:100 μM Incubation Time:After 50 °C or 37 °C for 15 min Result:Affected correctly folded triple helix structures and α,α′-dipyridyl on collagen secretion.
  • In Vivo
    ——
  • Synonyms
    Col003
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    328565-16-8
  • Formula Weight
    257.245
  • Molecular Formula
    C14H11NO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (194.37 mM)
  • SMILES
    C1=CC=C(C=C1)CC2=CC(=C(C(=C2)[N+](=O)[O-])O)C=O
  • Chemical Name
    5-benzyl-2-hydroxy-3-nitrobenzaldehyde

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ito S, et al. J Biol Chem. 2017 Dec 8;292(49):20076-20085.
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